What Happens When You Give Too Much HCG?
Photo Credit: EJE
Click here for EJE’s published abstract.
Commentary by Dr. John Crisler on October 19, 2017
It’s a pretty good example of what happens when researchers who do not have a cutting edge grasp of how to use these medications….although knowing what the study REALLY tells us is useful. Just not for the reasons they think.
HCG should never be administered at more than 500iu at a time. That is because there are only just so many Luteinizing Hormone (LH)--the natural hormone it mimics--receptors (where LH and HCG binds on the cells in the body, and subsequently causes an effect) in the body. And once you go above around (dosages vary greatly across the population) 500iu, you don’t get more testosterone, but you do make more estrogen and progesterone. Both are highly feminizing hormones in men.
Also, the body recognizes all that HCG, and subsequently downregulates the receptors for LH. That is the “desentization” you hear about all the time on the bodybuilding and men’s health forums.
My strategy in “Backfilling the Pathways” is to create as normal a hormonal environment as possible within the body. So, for HCG, for instance, that means mimicking natural LH concentrations. That means only 100-150iu of HCG per day. And if you think about it: if normal concentrations of LH (or its mimic, HCG) “desensitized” us, we would all be “desensitized”.
You see by comparing the two arms of the study, those who were given high dose HCG for a short period, then a long period, that it worked at first, then testosterone production fell off. That happened when the LH receptor density subsequently downregulated.
I’ve been using HCG at the appropriate doses for over fifteen years; long before it became vogue at that dose for the “HCG Diet”. And by the way, low dose HCG has never “reset the hypothalamus” of any of my guys, as they claim in the ads for the HCG Diet.
Once again, we see an example of how you need to be treated by a physician who works at the cutting edge of this field of medicine.
*Disclaimer: The use of the phrase "normal testosterone levels" is suspect right off the bat. There are vast differences between low-normal and high-normal. Higher LH in the face of low-normal is significant; but not in high-normal testosterone environments.*
Article Written by A.G.H Smals, P.W.C. Kloppenborg and Th. J. Benraad and an official journal of the European Society of Endocrinology. Acta Endocrinol 77 753-764 – THE EFFECT OF SHORT AND LONG TERM HUMAN CHORIONIC GONADOTROPHIN (HCG) ADMINISTRATION ON PLASMA TESTOSTERONE LEVELS IN KLINEFELTER'S SYNDROME
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